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Over the course of his career, Reilly's lent his artist talent to several other popular titles at Marvel and DC Comics, such as AMAZING SPIDER-MAN, INCREDIBLE HERCULES, SCARLET SPIDER, and LOBO.
He's also known for his work as a pioneer of digital storytelling, working closely with Comixology, to tell stories in ways that take full advantage of the digital platform, first with his creator-owned series POWERPLAY, and then with several digital-first series for Marvel, such as DEADPOOL: THE GAUNTLET, GUARDIANS OF THE GALAXY: BEST STORY EVER, DEADPOOL & CABLE: SPLIT SECOND, and others.

 

Reilly continues to draw comics from his home in Hoboken, NJ, as well as his Brooklyn art studio, Hypothetical Island.